Microsomes & S9

human-subcellular-fractionsThere are various subcellular fractions and they include homogenate, s9, microsomes and cytosol.  These products are valuable tools in drug discovery for studying the metabolism of your compounds.

Human Subcellular Products
  • InVitroCYP™ 150-Donor Human Liver Microsomes
  • InVitroCYP™ H-Class Human Liver Microsomes
  • InVitroCYP™ M-Class Human Liver Microsomes
  • Human Microsomes – Other Tissues
  • Human Liver S9

All microsomes and s9 products are tested by Quality Control to provide researchers with the best product in the market. Each preparation must pass set criteria for release.  Microsomes and S9 are tested for protein.  Human microsomes are tested for total P450. Enzyme characterization is performed on all human microsome and S9 products.

 CYPSubstrateMetabolitesUnits
AMOCYP2C8: Amodiaquine DecentralizationAmodiaquineN-Desethylamodiaquinepmole/min/mg
BUPCYP2B6: Bupropion hydroxylationBupropionHydroxybupropionpmole/min/mg
COUMCYP2A6: Coumarin 7-hydroxylationCoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
CZXCYP2E1: Chlorzoxazone 6-hydroxylationChlorzoxazone6-Hydroxychlorzoxazonepmole/min/mg
DEXCYP2D6: Dextromethorphan O-demethylationDextromethorphanDextrorphanpmole/min/mg
ECODMultiple CYPs: 7-Ethoxycoumarin O-deethylation7-Ethoxycoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
MEPHCYP2C19: S-Mephenytoin 4'-hydroxylationS-Mephenytoin4'-Hydroxymephenytoinpmole/min/mg
MIDCYP3A4: Midazolam 1-hydroxylationMidazolam1-Hydroxymidazolampmole/min/mg
PHENCYP1A2: Phenacetin O-deethylationPhenacetinAcetominophenpmole/min/mg
TESTCYP3A4: Testosterone 6ß-hydroxylationTestosterone6β-Hydroxytestosteronepmole/min/mg
UGTUGT: 7-Hydroxycoumarin glucuronidation7-Hydroxycoumarin7-Hydroxycoumarin glucuronidepmole/min/mg
TOLBCYP2C9: Tolbutamide methyl-hydroxylationTolbutamide4'-Methylhydroxytolbutamidepmole/min/mg