InVitroCYP 150-Donor Human Liver Microsomes

All human microsome products are tested by Quality Control to provide researchers with the best product in the market. Each preparation must pass set criteria for release.  Microsomes are tested for protein and total cytochrome P450.  Enzyme characterization is performed on all human microsome products.

 CYPSubstrateMetabolitesUnits
AMOCYP2C8: Amodiaquine DecentralizationAmodiaquineN-Desethylamodiaquinepmole/min/mg
BUPCYP2B6: Bupropion hydroxylationBupropionHydroxybupropionpmole/min/mg
COUMCYP2A6: Coumarin 7-hydroxylationCoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
CZXCYP2E1: Chlorzoxazone 6-hydroxylationChlorzoxazone6-Hydroxychlorzoxazonepmole/min/mg
DEXCYP2D6: Dextromethorphan O-demethylationDextromethorphanDextrorphanpmole/min/mg
ECODMultiple CYPs: 7-Ethoxycoumarin O-deethylation7-Ethoxycoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
MEPHCYP2C19: S-Mephenytoin 4'-hydroxylationS-Mephenytoin4'-Hydroxymephenytoinpmole/min/mg
MIDCYP3A4: Midazolam 1-hydroxylationMidazolam1-Hydroxymidazolampmole/min/mg
PHENCYP1A2: Phenacetin O-deethylationPhenacetinAcetominophenpmole/min/mg
TESTCYP3A4: Testosterone 6ß-hydroxylationTestosterone6β-Hydroxytestosteronepmole/min/mg
UGTUGT: 7-Hydroxycoumarin glucuronidation7-Hydroxycoumarin7-Hydroxycoumarin glucuronidepmole/min/mg
TOLBCYP2C9: Tolbutamide methyl-hydroxylationTolbutamide4'-Methylhydroxytolbutamidepmole/min/mg