InVitroCYP™ M-class microsomes

InvitroCYP-M-Class-MicrosomesHuman liver microsomes are subcellular fractions that contain drug-metabolizing enzymes including CYP enzymes, flavin monooxygenases, and UDP glucuronyl transferases. InVitroCYP M-class microsomes are designed to exhibit moderate CYP activity, ideal for clearance and metabolite identification studies. BioreclamationIVT' extensive characterization and tissue profiling process guarantees that each lot of InVitroCYP M-class microsomes will provide consistent and reproducible results for your metabolism and clearance studies.

 CYPSubstrateMetabolitesUnits
AMOCYP2C8: Amodiaquine DecentralizationAmodiaquineN-Desethylamodiaquinepmole/min/mg
BUPCYP2B6: Bupropion hydroxylationBupropionHydroxybupropionpmole/min/mg
COUMCYP2A6: Coumarin 7-hydroxylationCoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
CZXCYP2E1: Chlorzoxazone 6-hydroxylationChlorzoxazone6-Hydroxychlorzoxazonepmole/min/mg
DEXCYP2D6: Dextromethorphan O-demethylationDextromethorphanDextrorphanpmole/min/mg
ECODMultiple CYPs: 7-Ethoxycoumarin O-deethylation7-Ethoxycoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
MEPHCYP2C19: S-Mephenytoin 4'-hydroxylationS-Mephenytoin4'-Hydroxymephenytoinpmole/min/mg
MIDCYP3A4: Midazolam 1-hydroxylationMidazolam1-Hydroxymidazolampmole/min/mg
PHENCYP1A2: Phenacetin O-deethylationPhenacetinAcetominophenpmole/min/mg
TESTCYP3A4: Testosterone 6ß-hydroxylationTestosterone6β-Hydroxytestosteronepmole/min/mg
UGTUGT: 7-Hydroxycoumarin glucuronidation7-Hydroxycoumarin7-Hydroxycoumarin glucuronidepmole/min/mg
TOLBCYP2C9: Tolbutamide methyl-hydroxylationTolbutamide4'-Methylhydroxytolbutamidepmole/min/mg