Cell-Based Assay Services

BioreclamationIVT offers primary cell-based assay services for drug development which constitute the most accurate disease modeling and surpass cell lines, 3D organ culture and animal models. The assays cover many conditions, e.g., oncological, cardiovascular, metabolic, autoimmune, degenerative, genetic, aging-related etc.

From contract laboratory services to project management and consulting, your project will be tailored to answer your specific concerns.

Discuss Your Project With Us
  • Cell Toxicity
  • Drug Candidate Efficacy Testing
  • Mitochondrial Dysfunction
    • ATP, MTT
  • Oxidative Stress
    • ROS, RNS, Super Oxide
  • IC50/EC50 Determination
  • Pluripotency Marker Profiling
  • DNA Damage
    • PARP Assay
ClassCompoundReadout
AMPK AgonistAICAR
Metformin
Annexin-V detection; ATP concentrations
Annexin-V detection
AMPK InhibitorCompound CAnnexin-V detection
Chromatin RemodelerBRG1
BRM
OCT4, GCAP expression levels
OCT4, GCAP expression levels
FGF AgonistbFGFOCT4, REX1, hTERT expression levels
GSK3 InhibitorCHIR99021XIST RNA levels
Histone Modifier5-aza-dC
Trichostatin A
OCT4, GCAP expression levels
OCT4, GCAP expression levels
LIF/STAT3 AgonistLIF
IL-6
XIST RNA levels
XIST RNA levels
MAPK InhibitorPD0325901XIST RNA levels
STAT3 InhibitorNSC 74859XIST RNA levels
Tyrosine Kinase InhibitorCH5424802ATP concentrations

Available Biomarker Assays

AcylcarnitinesFree Fatty AcidsPolyamine Oxidase
AdiponectinFSHPolymyxin B
AGE-CMLGhrelinRAGE
Alpha-AntichymotrypsinGlucoseRANKL
alpha/beta-EstradiolGlutamateRBP-4
AMPK-alpha (total and phospho)HbA1cRetinoic Acid Receptor-alpha
Apolipoprotein A1hCGROS
Apolipoprotein BHDLS100
Apolipoprotein B-48HepcidinsCD14
Apolipoprotein C-IIIhGHSerotonin
Apolipoprotein EHistamineSHBG
ATPHomocysteineSphingomyelin
Bile AcidsI-FABPSphingosine
Brain Natriuretic PeptideICAM-1sVEGFR1/Flt1
C-peptideIFN-gammaT3 (total)
C-telopeptidesIGF-1T4 (free)
CeramidesIGFBP-3T4 (total)
CholesterolIL-10Tacrolimus
Corticosteroid Binding GlobulinmTORTaxol
CortisolMTT/XTTTBARS
CortisolMTT/XTTTBARS
CotinineN-telopeptideTBG
DHEA-SulphateNeopterinTCA-intermediates
DiacylglyceridesNeuropeptide YTGF-beta
DNA MethylationNGALTheobromine
DopamineNSETheophylline
DoxorubicinOPGTNF-alpha
e-SelectinOsteocalcinTopotecan
Endocannabinoidsp53Transferrin
Endothelin-1PARPTRAP-5b
EpinephrinPentosidineTriglycerides
Fatty Acyl CoAPhenylalanine EnrichmentTryptophan
FibrinogenPINPTSH
Folic AcidPolyamine OxidaseUncarboxylated Osteocalcin
FRAPPolymyxin BVasopressin

Note: This list is not all-inclusive. Please contact us if your study requires other assay targets.

We work with a variety of primary cells. Our expertise in cell culture allows us to produce data from even the most challenging cell types.

  • Adipocytes
  • Astrocytes
  • Bone Marrow Stem Cells
  • Cord Blood Stem Cells
  • Endothelial Cells
  • Enterocytes
  • Epithelial Cells
  • Fibroblasts
  • Hepatocytes
  • Lymphocytes (T cells, B cells)
  • Monocytes
  • Osteoblasts
  • PBMCs
  • Renal Cells
  • Skeletal Muscle Cells
  • Skeletal Myocytes
  • Smooth Muscle Cells
  • Splenocytes

 

 

 

Along with our biospecimens, we also provide a wide range of testing services from standard clinical assays.

Clinical Lab Testing

  • Albumin
  • CA 125
  • CA 19-9
  • CBC
  • pH
  • HCG value
  • PSA value
  • Rheumatoid factor
  • Total protein
  • Lipid profile (cholesterol and triglycerides)
  • Infectious agents: CMV/HIV/HBV/HCV