InVitroCYP 150-Donor Human Liver Microsomes

Quotation Form

150-Donor-MicrosomesHuman liver microsomes are a major tool for studying metabolite ID, reaction phenotyping, intrinsic clearance and inhibition studies. InVitroCYP 150-donor pooled liver microsome activity represents the population average. BioreclamationIVT microsomes are prepared from fresh human tissue which ensures a higher retention of enzyme levels. Every donor used in the pool has a quality tested enzyme profile

InVitroCYP 150-Donor Human Liver Microsomes, Mixed Gender, 10 mg

All human microsome products are tested by Quality Control to provide researchers with the best product in the market. Each preparation must pass set criteria for release.  Microsomes are tested for protein and total cytochrome P450.  Enzyme characterization is performed on all human microsome products.

 CYPSubstrateMetabolitesUnits
AMOCYP2C8: Amodiaquine DecentralizationAmodiaquineN-Desethylamodiaquinepmole/min/mg
BUPCYP2B6: Bupropion hydroxylationBupropionHydroxybupropionpmole/min/mg
COUMCYP2A6: Coumarin 7-hydroxylationCoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
CZXCYP2E1: Chlorzoxazone 6-hydroxylationChlorzoxazone6-Hydroxychlorzoxazonepmole/min/mg
DEXCYP2D6: Dextromethorphan O-demethylationDextromethorphanDextrorphanpmole/min/mg
ECODMultiple CYPs: 7-Ethoxycoumarin O-deethylation7-Ethoxycoumarin7-HCG, 7-HCS, 7-HCpmole/min/mg
MEPHCYP2C19: S-Mephenytoin 4'-hydroxylationS-Mephenytoin4'-Hydroxymephenytoinpmole/min/mg
MIDCYP3A4: Midazolam 1-hydroxylationMidazolam1-Hydroxymidazolampmole/min/mg
PHENCYP1A2: Phenacetin O-deethylationPhenacetinAcetominophenpmole/min/mg
TESTCYP3A4: Testosterone 6ß-hydroxylationTestosterone6β-Hydroxytestosteronepmole/min/mg
UGTUGT: 7-Hydroxycoumarin glucuronidation7-Hydroxycoumarin7-Hydroxycoumarin glucuronidepmole/min/mg
TOLBCYP2C9: Tolbutamide methyl-hydroxylationTolbutamide4'-Methylhydroxytolbutamidepmole/min/mg